Oncometabolites Mediate Alterations in Covalent Cytosine Modifications in AML
نویسندگان
چکیده
16 wHat’s On tHe weB Cytogenetically normal acute myeloid leukemia (CyN-AmL) makes up 40 to 50 percent of cases of adult AmL. The heterogeneous nature of CyN-AmL makes prognosis uncertain, and despite the clinical heterogeneity, induction therapy remains largely uniform. Technological advances in DNA sequencing, however, are providing new insights into the molecular basis of CyN-AmL, suggesting new diagnostic and prognostic categories and novel approaches to therapy.
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تاریخ انتشار 2012